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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ce8fb601fff12b39c22e4875b6d903e2760bd2033da1d09552fba9a2dbcb9c88' 
  AND token = '+WTERMfEoZ5fnjpe4pDHUCkQJizK5qR0YRMdiwZ5jlU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}