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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4b27ea6135e6e5a80793756d9316842ff17d2f1e3b4a22a91cbaf8af56f7d23b' 
  AND token = '4V1vkbCsgNKhCc2wlE3MSUFIVqKD6a8IMHHOxr1iHYg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}