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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '16e2d33b5545fe7ba6401632fa8b09ac50a823ed9e927004ffcb1159e4fb0be5' 
  AND token = 'nu6aVPIulp3HnLIWVRpFsL0gO+p1/cWzSTD7jEXujMg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}