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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2cb2eab37534a23e24f645a73a24dce37321d8d4f8f858bbb69cc0551d28f296' 
  AND token = 'KHBL+HROnebhDAN0hJoGNOiUTsV6kcyjX8VTkpFqsUk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}