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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8d3016f9397df1debf91b309f81880529839dd4b3689720b1a4760126b7b0664' 
  AND token = '7UKK2I3Y1HXfb9550r+s+RJ5XyDWq4FSlGt1bgv3pTQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}