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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '12978756960a7163abc281e2772b471c020cf309e1bb3ed07d258453320f32e4' 
  AND token = 'BPtX+MU9Ll3Oiv6Qn6MSkyNnV8pDDb46UKi8SjBYDbY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}