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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '492a1a2085a01a0f434827e713bbbecb8dd5c3afcaf0c32c721f5ecb4ed3bc63' 
  AND token = 'wI+9EEWc/9qwEGJzo9hLTyWWJTYF8m2OqmZNcrEf3g4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}