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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ec121c18b5fa386584baf7a84df97d602264452e1b4a33c19ed103d39cc3b18c' 
  AND token = 'AloQBKa3tvAcehDiTmTlU1PEF07reXGXFNid08OEEl0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}