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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0750a6f6da5c2877f423ffa3ae0211a305d5ce101d1027e8c8e883560a3b445a' 
  AND token = 'lkZGlGdrLL10mwEher4YtUtAPymjJe5zxWfWT1hzSYY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}