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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '18c982d72d0d8a49f9e7ef5f898c6452dc05791a2452a0d2ef49e19e35548769' 
  AND token = 'jyeRsOChCBtRZFIYnja3o7wqmXK34KU3AoKvtZqwAv4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}