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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '12b9db1febcfa113e765f823bdac15e017f105e3a842fb12dc94e0fa527ca1a0' 
  AND token = 'N+9WHoroDDtu3uwFV2U0v7C0ZT1zCN25BQGNoePEkNY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}