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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45d45d8a7ba9e8e9e1d4e92d0b4868e6ff59c5725de121dde173e3b3b8d8e065' 
  AND token = 'ePUf2koAtSTdBhgggH9idADszfsXRsFum36AMn9vg64=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00032

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}