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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65571840e4a1034bdcf7e548e7358a91b64503a26a62b9ba7a1fd8b46c3746c8' 
  AND token = 'qxBOfF7vlW9jOZDIXGOzUrvTePr3YTEP7T3dSGH7PoI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}