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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45e76b0abc867f93c070fd9f6042f38a3eefc3c4af2fbc53353a1cb03817cc1b' 
  AND token = 'Aap+4o2CsjMqqqFmn4I+U2Df/Ep+Ld88zhLlpV6Z6BA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}