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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22ed9f5d57493f935f9feb5b292e9eb4075ff380b701fc13892c8675a5f20184' 
  AND token = '65L87dqjTBIis1f/9X+xF9SRqaq8fIBFBS2q1tZspCc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00037

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}