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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '18c6d571c2857d5e9faa4c4be35a484faf0552ab57b5008c94e0781b2791e7a9' 
  AND token = 'p4n1Q+jw4RARyZz7XWnf+ynVDKJEZVMr5zI2/rw7JMo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}