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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d66e27570f51bd0207994a4479aa9055048bd71e5bd1b84975f4f00055ef7f1' 
  AND token = 'r9eybNcXXIIzqes4f++B10kSg/BqRQUCeLVTvUVD3h0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}