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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '38cd5c427a5e5b04a139604eb0e36e4827a4cf6e48de7383b408ae1613613b61' 
  AND token = '+az/9mrrkMaR6UqSmWTDnW0pNsTxUXHGN7qKxrkHxfE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}