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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53ccc29bdd7b234a7c13b165bf4774cb243330a154e624412f666c32ad15dd89' 
  AND token = 'uUG6JmeQ09Lh29dFZwbXoNFV5lMP+l4gJdRtkEOjOF8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}