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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6a08b72bec704ff02c9a5568396e757c443b07b4567c397a138559348b2e9b01' 
  AND token = 'X2gKdDJMBUxeH7sasCxqxoiIoTnJoKdoxw3n9aVv3kA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}