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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '720a24024651d9dc782c2be844e7480f7cfd78651de174a398ceb0c390df26dd' 
  AND token = 'iIiaoY+MbnAt6vcWdDl+DFsZtL41CNDzEbRNI3RZJdo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}