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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c4d0278df6cd7e1f6a04943fefb7b5f913ffcf62b00f4868d84caa7f66270681' 
  AND token = 'UHqCuN0bJWdQja2Qf8Is8vGgqdsgcpxplqetQuqIGV0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}