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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '332153463e88f7bd2cdb16cdda2b6b35548d652606874cb6a658ed8f068278a4' 
  AND token = '2DQsI/CmaPWp88n7NMwkeyuq9Y891GVCajpgov52cik=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}