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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f49c283b2ca717aea3fab57c306a0d65c6881c86898f4a83601bbe56c7e643f5' 
  AND token = 'e0CUVFnNlfqEVCrHmX6r7XmY3p6pIH1PVHCu0EMkhEc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}