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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65c4185391848a69b6eb54fe1b56d4f674aa6fb504df732c647f144f3e0c44b8' 
  AND token = 'QzBqDQFhfYy6P6+JoHcQwyx1sDuifSin4SzYtj9cDv8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}