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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6b0c1ebde7aefbdcd10203494c3f8d807d77e9b50677da808dfc2c93365a88d2' 
  AND token = 'Fru0Kmh8QBjE4k43YwWRhnc6P0hWBU934RQ/2/lFQN0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}