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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80ca28d29cc868f883c3135e98b991f0da16d3b29800ed76571d4d0cc341b215' 
  AND token = 'j9mLMkkkSgqZ7qNOAmcuWwMLGLnY7yfs70tI+jFxNaM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}