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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '289d88000e9d159f64e81ba1326456c54245fda79c2e610c40a24a91867afbae' 
  AND token = '1i9F56GQUbnARDY1M8UI1wk7+Q/W+u7HyXmDygR7htQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}