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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '74d99beca6f2b0d22fb75fe3b486cecb23d61d1c5c23fc73543ff51dda4f38a4' 
  AND token = 'iSM4XCZBYnJQpg5z6WCNzbOeo9Qq0ne+p55okWnCDO8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}