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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '743c41a0a892c2d71610cf5c76cd7d8e6500a5148f0815ba2a30191105ff7172' 
  AND token = 'S6haTXyWTxQbkBzhfMQFcoYd+X0LjKW0iU5KYRJvLSM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}