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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'de4773378cf0da041f7136b1145a6f1fab0a80e69df4631d4d12a590caa81856' 
  AND token = 'JL1u0hDBpi/+eu+BRmdhNmVin2f0l6IBT664G1g41bM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}