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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '459e9c03c1bfed4a34fce1c0c250595e711bd2f533ff71ddade16a64d7a7aa53' 
  AND token = '21ekvA8EsEFLlMomUTt/FNKQNUj+OWiw8nJxVUMYtos=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}