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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a49dc09a9c95f2501de00283bf22757021f304f3f2d7f43e091a921a05c3a143' 
  AND token = 'Td75awOFnLEtDKwp5y4H6RO2wMtNe83yuL1lAdU4jnQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}