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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5fea158a06d6b1493a1623c3dc7c8c026a06019f14c02a38ee70912be0bd5776' 
  AND token = 'uuoQb3Uaf81yfY3BGT9+MmbikuLbNz4gQwtCVnzh3Ac=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}