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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd281c78fcf8e1ba32391a118f42c53182e22ccf7716f21cf4be5dcef68c1af26' 
  AND token = 'C2CMf2Dfjtnba/P3Y5pn5OA9Gcj2TChFRRK8Lq9f23Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}