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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cfe5d98d403ba5f17359c1130be0fb16446a73e0278b260809015a69cf6ae196' 
  AND token = 'W1Qqqb2fkiXu5HF/l1zRmEkqGLGvHv6bdpCVuV1IVF0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}