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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '187cf42e64ecead3201a55342f29bb77752f15f22d521a8b879fd3087017a393' 
  AND token = 'vSfHmrwBt1K4oV0B6hH3CMy+BAK2b4aKMtSOwqZAuu4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}