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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f29600ba825b527a20f82367f3daff8bda29e90c16a430682e726ecaa648f612' 
  AND token = '8+3nHZ2hXE0HUoiExmIA794dlXui9cidQ2a8EmLSLU8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}