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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9de754bfb47b1b327083d386b89c423a960d8f7f9803fac8b2bd4e5aaa47aafd' 
  AND token = 'VwsWa3XtpNvc7+FDx28UPgqg4FPLjwYbZ0aF+ofpsFo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}