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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e1c9b5b27f1edefb01ba069df207943ac36c80c3d18bf313f839a0281c53ffc1' 
  AND token = 'wq8GvRFm+xGUCpE7YfpBm4iN9Hys9BYKBQSlwQ2XEGM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}