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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ab25d5c9003a847024a8551c88af6d4081a5d3e52a5ec4afb9c405dcf8cfeaf2' 
  AND token = 'bVLIJJT9ts00kjE0rKtLUBTiLVopFxSuc3Zw+s8RGeI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}