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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8047423325a1b0d08cdc833f25b9464eff8a0c16f8bd4ecd44d2589e66cb3da0' 
  AND token = 'VZcoIDX6UBQRTAIckWvYtjFDyuNbkvTY9bMe+V5fOyg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}