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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2564c63b563df76811fcd72867321dc2d6bf647ff8ceb21a9312d78e02d9c1b3' 
  AND token = 'vLQ0D310DqmPoBODgeomxAwM3t65hzMFGsvgkjnzjQE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}