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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4e1dc7c7720b4fb523e23202717219f028c9c75e340e42cc66d9d7a1843e7829' 
  AND token = '9w/VSeinaYLeepV19cZKZ9HRivZrmI0Zv1SVys/ahr8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}