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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b114f34a08db168f2db3227942133f27f07a105d53c3248e5cbfb35f1259ab1c' 
  AND token = 'Vd3TTzFZH4bE8LWlEDEqdp1e7Eh80A+IPXxfyR9HAno=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}