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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ed46ec6e2794749356c4fc336f40cb95b3c5225ed21872f96063decedb771b1c' 
  AND token = 'VtOpOuR8VfrbBsWX9vsceCkOtPnL/5+PYqusRBxkgCE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}