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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '100da8a1808cd1b7906da42e44bb7933a889b68b0cf6a451b31ff6eb0797a274' 
  AND token = '+oZgVnw6lLt6Et3m/sQt/LK8O2akl3jB2Bs1PHHe5ek=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00045

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}