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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48e5b0861ed867db7b92ecd63ec79699b4e0ae66e7de98bf06fcc18531a21f80' 
  AND token = 'okENl7Xb2cJxY+73I/hl+ZYo7bE0zPHt3Jkpbn5UkLw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00073

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}