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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '220063c9e7c5dd4bb1beb12b16c4347a65b9ad1d071e745d8d7041e04a1e63b3' 
  AND token = 'r3kQZWukwS5CrPszh7qdnVm4sUHfz39aDPvrjTiNt/8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}