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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '645e80381b80ef41e25da5e64f9aeedab213536646a7c9f7012206fa5f39de86' 
  AND token = 'kq/s7oLaIRLBdMXZFfVW5g8kKRGvFt924xiZ7msJMSc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}